BioSpace Names 15 Top Startups to Watch in 2026

DES MOINES, Iowa, Jan. 7, 2026 /PRNewswire/ — BioSpace, the leading life sciences news and careers site, has announced its 2026 selections for the industry’s most promising up-and-coming companies.

The NextGen Class of 2026 list showcases 15 innovative organizations demonstrating exciting potential. This is the 12th year BioSpace has highlighted the most anticipated new biopharma companies from across the U.S.

BioSpace‘s editorial team considered multiple factors: financing, collaborations, pipeline, growth potential and innovation. This year’s list includes companies that announced initial, seed or series A rounds between October 1, 2024, and September 30, 2025.

“Startups faced a challenging funding and regulatory environment in 2025,” said BioSpace CEO Josh Goodwin. “The successful raises of these companies shows how well they have been able to adapt and navigate this dynamic landscape.”

BioSpace considers organizations across all therapeutic areas. RNA therapies, antisense oligonucleotides and CAR Ts are among the products being developed. Winners include Kardigan, Light Horse, Haya and City Therapeutics.

“It was a smaller NextGen class this year, given the tight funding environment,” said BioSpace Managing Editor Jef Akst. “The companies highlighted standout not only for their raises but their innovative science, a lot of which has already attracted Big Pharma partners.”

“Picking the annual NextGen list is a highlight of the year for BioSpace‘s editorial team. It gives us a window into the biotechs that will be driving the industry’s innovations and headlines in the years to come,” said BioSpace Senior Editor Annalee Armstrong.

Last year’s NextGen list included obesity startup Metsera, which made headlines with a dramatic bidding war that eventually ended with a $10 billion Pfizer buy. Other 2025 NextGen members continue to be closely watched by the industry, such as Seaport Therapeutics, which accrued multiple best-in-biotech accolades.

The NextGen: Class of 2026 List

Arnatar Therapeutics, Axonis Therapeutics, Bambusa Therapeutics, City Therapeutics, Corsera Health, Dispatch Bio, Haya Therapeutics, Helicore, Kardigan Therapeutics, Kivu Bioscience, Light Horse Therapeutics, Newleos Therapeutics, Renasant Bio, Stylus Medicine, Trace Neuroscience

View complete NextGen lists from previous years: Class of 2025, Class of 2024, Class of 2023, Class of 2022, Class of 2021, Class of 2020, Class of 2019, Class of 2018, Class of 2017, Class of 2016, Class of 2015.

About BioSpace

BioSpace provides essential insights, opportunities and tools to connect innovative life sciences organizations and talented professionals who advance health and quality of life across the globe. BioSpace is the leading source for careers and news for life sciences professionals in the United States. 

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SOURCE BioSpace