6 Best Cross-Chain Crypto Exchanges for Businesses in 2025

Crypto exchanges are widely used online platforms for buying, selling, and trading cryptocurrencies. It was initially difficult to transfer or swap crypto coins because of blockchain isolation. Now, cross-chain crypto exchanges or cross-chain swaps allow users to exchange coins and tokens instantly. 

A cross-chain crypto swap or exchange enables swift transfers of tokens built on distinct blockchain networks. A user can easily swap Bitcoin (BTC) for Ethereum (ETH) without manual bridging or a central authority. 

Cross–chain exchanges essentially bridge hundreds of blockchain networks. Thus, they make crypto assets interoperable, more efficient, and accessible. But which cross-chain cryptocurrency exchange is the best for your business? 

One of these 6 Best Cross-chain Crypto Exchanges could be the best pick for your business. Check their reviews to make an informed decision now. 

Top 6 Cross-Chain Crypto Exchanges for Businesses in 2025

There were a few blockchain networks in the past, but today, hundreds of blockchains power various crypto projects. Cross-chain crypto exchanges and swaps allow traders and investors to quickly swap preferred tokens without leaving the platform. 

The following are the 6 best cross-chain exchanges for businesses:

1. ChangeNOW

Emerging as the most advanced Web3.0 financial infrastructure provider, ChangeNOW provides enterprise-grade exchange, crypto payment, and asset management solutions.

Supporting over 1,500 crypto assets and 150 blockchain networks, ChangeNOW serves SMEs and enterprises in the iGaming, FinTech, investment, and lending sectors. Businesses are integrating its cross-chain exchange on their portals to help their customers swap cryptos instantly. 

Business organizations have integrated ChangeNOW’s crypto exchange API, white label solutions, and exchange widget. Its exchange solution helped clients provide their customers access to a cutting-edge multichain swap without leaving the app or the website.

Why ChangeNOW Should Be Your Top Pick?

It offers enterprise-ready exchange infrastructure for businesses with 99.99% uptime. With a 350MS response time, ChangeNOW’s exchange tool performs millions of swaps each month. 

Supporting over 150 blockchains and more than 1,500 coins, ChangeNOW provides true cross-chain interoperability. Its cutting-edge infrastructure can aggregate liquidity from top centralized and decentralized exchanges to provide instant swaps and ensure the best exchange rates. 

ChangeNOW allows clients to self-list tokens, bypass CEX listing, take advantage of cold and hot storage for top-notch security, and pick between one-way or two-way bridge options. 

ChangeNOW assigns a personal manager, who guides the client during the multichain bridge integration process. The manager will answer all your queries, and the client will get a tailored solution to share with customers and the business community. 

2. Symbiosis Finance

Another top-ranked contender on our list is Symboisis Finance. Operating as an all-in-one cross-chain swap solution, Symbiosis Finance supports more than 45 EVM and non-EVM networks. 

Clients get a unified interface that makes multi-chain operations quite simple for the business. The cross-chain exchange solution provider comes with an MPC-based non–custodial network. It ensures your business maintains complete control over the funds. 

Key Features:

• Supporting over 430 token pairs and more than 45 blockchain networks. 
• Best for non-custodial, trust-minimized bridging across multiple networks.
• Offering an average transfer speed of 3-5 minutes. 
• It uses DEX routing and gas fees to charge dynamic fees. 
• Symbiosis’s cross-chain crypto exchange solutions are best-suited for multi-chain DeFi users and crypto swaps.

3. Rubic 

Rubic is a crypto exchange aggregator offering cross-chain solutions for businesses. Just like ChangeNOW, Rubic offers API, Widget, and SDK through which an enterprise can access its cross-chain swap solutions. 

Businesses can integrate Rubic tools directly on their applications or other platforms to offer instant crypto swaps to customers. Rubic is in a strategic partnership with ChangeNOW. This collaboration enables Rubic’s clients to leverage cross-chain solutions offered by ChangeNOW. 

Key Features:

• API and SDK integration into dApps, NFT marketplaces, wallets, and games.
• It supports swapping more than 15,500 cryptos across hundreds of blockchains. 
• It can aggregate liquidity using Best Rate Finder from various bridges and DEXs to discover the most cost-efficient transaction routes. 
• Assuring unbeatable security by deploying the best security measures.

4. Axelar Network

Axelar Network is also a reliable choice for businesses looking to integrate cross-chain interoperability solutions. It provides developer tools and APIs instead of offering a complete, out-of-the-box crypto exchange solution. 

A business can link its app or website to 60 blockchain networks securely through Axelar’s solutions. Businesses building complex cross-chain apps, lending solutions, and tokenized real-world assets (RWAs), prefer Axelar’s connectivity infrastructure. 

Key Features:

• Offering universal cross-chain connectivity for seamless message, token, and data transfer. 
• General Message Passing to enable cross-chain smart contract calls. 
• Offering a suite of developer-friendly APIs and SDKs. 
• Collaborating with the leading ecosystem to liquidity access, broad chain compatibility, and enterprise support.

5. deBridge

deBridge powers instant swaps across multiple blockchain networks. This cross-chain crypto exchange solutions provider offers Interoperability-as-a-service (IaaS). 

Business organizations and crypto ecosystems can use this subscription to access deBridge’s advanced cross-chain infrastructure. By using this subscription, a business can integrate cross-chain functionality into its services and apps. 

Key Features:

• It can empower your customers to carry out cross-chain transfers across 100+ blockchains. 
• A business can embed cross-chain swaps into its platform using the deBridge API and widget. 
• Arbitrary asset conversion. 
• Offering a range of developer tools.

6. Stargate

Stargate is providing a cross-chain DeFi protocol for businesses. It enables safe and instant transfer of crypto assets between distinct blockchains. Stargate operates like a unified liquidity layer, but it is not exclusively for businesses. 

Stargate is a reliable cross-chain crypto exchange solution provider for any business operating in the DeFi space. Businesses can utilize it to transfer crypto assets across various blockchains, thereby accessing liquidity pools, markets, or decentralized applications. 

Key Features:

• Business enterprises can manage their operations across various chains without creating separate accounts on each chain. 
• Trading firms can use Stargate’s solutions to quickly move assets and benefit from price differences on those chains.
• Businesses can provide their users with cross-chain functionality by integrating Stargate on their platforms. 
• A business can use a single pool to provide liquidity across different DeFi protocols on different blockchain networks. 

Conclusion

Among all 6 reviewed platforms that offer cross-chain crypto exchange solutions, ChangeNOW has the best interoperability solutions. Its B2B tools are designed to help businesses expand their services across multiple networks and provide affordable crypto swapping solutions. However, you should carefully consider each platform to make a well-informed decision.