Spruce Biosciences, Inc. (SPRB)

NASDAQ

$41.34

$+1.36

(+3.37%)

Previous Close: ⁦$40.40⁩

Market Closed

Spruce Biosciences, Inc. (SPRB) Live Price Chart

Last updated: ⁦2026-10-21 04:13:00⁩. Prices reflect the latest closing data and will resume updating on the next trading day. Stock price data is sourced from Massive.

Summary

Spruce Biosciences, Inc. (SPRB) operates in the PHARMACEUTICAL PREPARATIONS sector and is listed on NASDAQ. The stock is currently priced at $41.34, with a market capitalization of $113.95M and a P/E ratio of --. Over the past 52 weeks, its price has ranged from $38.06 to $154.95. This page covers its latest market performance, valuation, price trends and company information.

Key Market Data

Market Cap	$113.95M
Open	$40.57
Day's High	$2,670.00
Day's Low	$4.28
Previous Close	$40.40
Volume	48.69K
Average Volume	79.40K
P/E Ratio	--
52-Week High	$154.95
52-Week Low	$38.06
Dividend Yield	--
Earnings Date	--

Spruce Biosciences, Inc. (SPRB) Latest Closing Stock Price

Spruce Biosciences, Inc. (SPRB) last closed at $40.40 as of 2026-10-20 23:58:00, unchanged from the previous close of $40.40.

During the latest regular trading session, SPRB traded between $4.28 and $2,670.00, with a volume of 48.69K shares. The closing price was near the lower end and near the lower end of its 52-week range.

Spruce Biosciences, Inc. (SPRB) 7-Day Stock Price Change

Over the past seven days, Spruce Biosciences, Inc. (SPRB) moved from $44.05 to $41.34, representing a decline of 6.16% ($2.71).

The stock traded between $38.06 and $45.04 during the period. The latest price is near the middle of the 7-day range, indicating strong downward.

The average daily volume was 84.59 thousand shares, up versus the previous seven-day period, indicating higher trading activity.

SPRB 52-Week Price Position

Position in Range: 2.8%

52W Low$38.06

52W High$154.95

SPRB is currently trading at $41.34, placing it 2.8% of the way from its 52-week low of $38.06 to its 52-week high of $154.95. This percentage reflects the stock's relative position within its 52-week trading range, not its valuation or future performance.

What is Spruce Biosciences, Inc. (SPRB)?

Spruce Biosciences Inc is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with unmet medical needs. The company develops biologics and small-molecule product candidates aimed at addressing diseases with unmet medical needs and limited or no approved therapies. Its product candidate, TA-ERT for the treatment of Mucopolysaccharidosis Type IIIB (MPS IIIB), is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) intended as an enzyme replacement therapy for patients who lack rhNAGLU enzyme activity. TA-ERT is designed to restore rhNAGLU enzyme activity in the central nervous system following intracerebroventricular injection and promote clearance of heparan sulfate in the brain.

Spruce Biosciences, Inc. Information

Industry	PHARMACEUTICAL PREPARATIONS
Employees	8
Exchange	NASDAQ
Company Website	https://www.sprucebiosciences.com

How to Buy Spruce Biosciences, Inc. (SPRB) Stock on MEXC

Eligible investors can buy real shares of Spruce Biosciences, Inc. (SPRB) through MEXC RealStocks. Follow these three steps to open a RealStocks account, transfer USDT, and place a US stock order.

Step 1: Open and Verify Your RealStocks Account

Log in to the MEXC App, go to Trade → RealStocks, and select Open Account. Complete the required account-opening and identity verification process with MEXC's partner licensed broker.

Step 2: Transfer USDT to Your RealStocks Account

Go to Wallets → RealStocks and transfer USDT from your Spot Account to your RealStocks Account. RealStocks are quoted in USD, while account funding can be completed using USDT.

Step 3: Search for SPRB and Place Your Order

Open the RealStocks trading page and search for SPRB. Select a market or limit order, enter the price and quantity as required, review the order details, and submit your order. Once filled, the corresponding real shares will be held in your RealStocks Account.

Frequently Asked Questions (FAQ)

1.What is Spruce Biosciences, Inc. (SPRB) stock price today?

Spruce Biosciences, Inc. (SPRB) is currently trading at $ 41.34, up 2.32% ($0.94) from the previous close of $ 40.40. Intraday prices update in real time during regular trading hours.

2.Is SPRB stock going up or down today?

As of 2026-10-20 23:58:00, SPRB is trading at $ 41.34, up 2.32% ($0.94) from its previous close of $ 40.40. The stock has traded between $ 4.28 and $ 2,670.00 during today’s regular session. Past price movements do not guarantee future results.

3.What is SPRB pre-market price?

As of 2026-10-20 23:58:00, SPRB is trading at $ 40.44 in pre-market trading, up 0.10% ($0.04) from the previous close of $ 40.40. Pre-market prices reflect trading activity before the regular session opens and may experience lower liquidity and higher volatility.

4.What is SPRB after-hours price?

As of 2026-10-20 23:58:00, SPRB is trading at $ 41.18 in after-hours trading, up 1.92% ($0.78) from the regular-session close of $ 40.40. After-hours prices may differ from the regular session’s opening price due to lower liquidity and wider bid-ask spreads.

5.Is SPRB stock trading now?

SPRB trades on the NASDAQ exchange during regular hours, Monday through Friday, 9:30 AM to 4:00 PM ET, excluding public holidays. Pre-market and after-hours trading are also available through select brokers outside these hours.

6.Where does SPRB sit relative to its 52-week high and low?

Over the past 52 weeks, SPRB has traded between a low of $ 38.06 and a high of $ 154.95. At $ 41.34, the stock is positioned 2.8% of the way from its 52-week low to its 52-week high, providing context for its current price within the one-year trading range.

7.What sector is Spruce Biosciences, Inc. in?

Spruce Biosciences, Inc. (SPRB) operates in the PHARMACEUTICAL PREPARATIONS sector. Sector classification helps investors compare it with companies exposed to similar market trends and competitive conditions.

8.What is Spruce Biosciences, Inc.'s market capitalization and where is it listed?

Spruce Biosciences, Inc. is listed on the NASDAQ exchange with a market capitalization of $ 113.95M. Market cap reflects the total market value of all outstanding shares and is commonly used to classify stocks by size.

9.How is SPRB valued in terms of P/E ratio and EPS?

SPRB trades at a P/E ratio of --, based on trailing-twelve-month EPS of $ -17.87. P/E ratio compares the stock price to earnings per share and is a common starting point for assessing valuation relative to peers.

10.Does Spruce Biosciences, Inc. pay a dividend?

Spruce Biosciences, Inc. pays an indicated annual cash dividend of $ 0.00 per share, with a current dividend yield of 0.00% based on the latest share price. Dividend policies are subject to change at the board's discretion.