Buy Crypto
Markets
Spot
FuturesBTC
Earn
Event Center
Rewards Hub
More
0-Fee Fest

52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are broadly higher today, with the Dow Jones up ⁦0.03%⁩, the S&P 500 up ⁦0.60%⁩, and the Nasdaq Composite up ⁦1.18%⁩. Market breadth is also positive, with 2,687 stocks advancing versus 2,431 declining, indicating a broadly bullish bias.

Dow Jones
52,377.57
Change
+15.99+0.03%
S&P 500
7,722.6
Change
+45.83+0.60%
Nasdaq Composite
26,477.811
Change
+308.43+1.18%
24H Gainers
2,687
24H Losers
2,431

52 Week Gainers

#Stock52 Week Range
4301Aprea Therapeutics, Inc.APRE$0.52+17.66%187.48K$6.55M$0.41 - $1.490.00%
4302Liberty Defense Holdings, LtdDETX$1.77+0.59%25.18K$10.05M$1.36 - $4.980.00%
4303Snail, Inc.SNAL$2.32-5.19%42.17K$7.45M$1.70 - $10.800.00%
4304Boost Run Inc.BRUN$8.10+8.29%4.95M$574.30M$6.94 - $42.000.00%
4305Cardiff Oncology, Inc.CRDF$0.88+10.27%611.84K$68.77M$0.76 - $3.310.00%
4306Hertz Global Holdings, Inc.HTZ$2.00+2.58%14.66M$711.12M$1.45 - $8.180.00%
4307Wetouch Technology Inc.WETH$0.91-8.08%38.70K$12.18M$0.86 - $3.680.00%
4308Oncolytics Biotech, Inc.ONCY$0.47-1.46%834.88K$61.10M$0.44 - $1.320.00%
4309QVC Group, Inc.QVCG$7.50+2.88%163.87K$406.50M$7.12 - $20.000.00%
4310Fulcrum Therapeutics, Inc.FULC$3.71+1.92%1.68M$282.68M$2.83 - $15.740.00%
4311Giftify, Inc.GIFT$0.45-6.97%283.80K$15.98M$0.38 - $1.290.00%
4312Cerebras Systems Inc.CBRS$119.27+9.58%13.34M$26.33B$106.13 - $386.340.00%
4313QT Imaging Holdings, Inc.QTI$2.29+0.43%32.52K$31.60M$2.22 - $7.600.00%
4314Arqit Quantum Inc.ARQQ$17.99+11.23%220.52K$281.62M$11.52 - $49.330.00%
4315Kalaris Therapeutics, Inc.KLRS$1.86+3.33%49.01K$44.18M$1.78 - $11.880.00%
4316Celularity Inc.CELU$0.80+6.91%216.82K$25.86M$0.56 - $2.550.00%
4317GameSquare Holdings, Inc.GAME$2.26+0.89%68.74K$29.53M$1.88 - $5.970.00%
4318Stratum Holdings Corp.SRTM$0.24-17.53%2.72M$137.90K$0.21 - $0.680.00%
4319Lanvin Group Holdings LimitedLANV$0.79-4.13%4.58K$98.97M$0.77 - $2.310.00%
4320ZoomInfo Technologies Inc.GTM$4.34+1.76%3.32M$1.26B$2.54 - $12.310.00%
4321ClearPoint Neuro, Inc.CLPT$9.69+7.08%631.99K$295.46M$8.27 - $27.270.00%
4322SIGA Technologies Inc.SIGA$3.21+1.43%289.93K$230.28M$2.83 - $8.540.19%
4323SAGTEC GLOBAL LIMITEDSAGT$0.73-1.36%157.42K$14.66M$0.38 - $3.390.00%
4324Stellantis N.V.STLA$4.16+1.72%48.00M$11.79B$3.92 - $12.220.00%
4325FBS Global LimitedFBGL$2.08-6.92%5.91K$3.04M$2.04 - $14.000.00%
4326Teamshares Inc.TMS$4.72-2.44%108.85K$391.42M$4.58 - $13.200.00%
4327AEye, Inc.LIDR$1.03+4.14%414.79K$48.31M$0.81 - $3.050.00%
4328Ready Capital CorporationRC$1.19+8.26%1.86M$195.75M$0.96 - $3.220.29%
4329Gelteq LimitedGELS$0.46+0.69%24.59K$4.88M$0.39 - $2.010.00%
4330Eve Holding, Inc.EVEX$1.67+5.03%844.83K$580.23M$1.41 - $5.160.00%
4331Tigo Energy, Inc.TYGO$0.94+0.54%374.50K$71.66M$0.79 - $5.330.00%
4332Avalo Therapeutics, Inc.AVTX$6.75-0.22%2.34M$362.11M$6.53 - $24.270.00%
4333Definitive Healthcare Corp.DH$1.11+1.85%246.51K$118.81M$0.61 - $3.020.00%
4334NewcelX Ltd.NCEL$2.73+5.44%12.05K$15.77M$1.83 - $7.640.00%
4335Array Technologies, Inc.ARRY$3.40+7.78%4.83M$523.01M$3.09 - $12.230.00%
4336Grande Group LimitedGRAN$1.13-8.87%11.06K$28.98M$0.78 - $5.910.00%
4337Neighborhood Intelligence, Inc.NXH$1.59+1.27%4.30M$157.44M$1.32 - $4.550.00%
4338Archer Aviation Inc.ACHR$4.22+7.87%25.21M$3.25B$3.68 - $11.720.00%
4339Whirlpool Corp.WHR$27.44+2.95%11.57M$1.79B$24.00 - $94.820.10%
4340Spruce Biosciences, Inc.SPRB$45.66+2.96%78.08K$131.22M$38.06 - $138.450.00%
4341ADC Therapeutics SAADCT$1.59+5.30%974.54K$202.86M$0.78 - $4.980.00%
4342ONE Nuclear Energy Inc.ONEN$1.28+4.00%19.02K$141.03M$1.22 - $3.650.00%
4343Global Engine Group Holding LimitedGLE$2.47-5.08%24.36K$5.65M$2.33 - $10.900.00%
4344Eikon Therapeutics, Inc.EIKN$5.55-0.18%615.80K$393.24M$5.44 - $17.400.00%
4345Delixy Holdings LimitedDLXY$1.68-3.18%17.72K$5.89M$1.65 - $22.250.00%
4346Rectitude Holdings LtdRECT$1.27-5.47%6.85K$19.61M$0.96 - $4.450.00%
4347Nouveau Monde Graphite Inc.NMG$1.01+10.53%225.72K$334.09M$0.87 - $3.600.00%
4348Solarmax Technology Inc.SMXT$4.35+2.35%9.90K$20.63M$1.82 - $15.240.00%
4349Sunrun Inc.RUN$7.54+3.58%7.06M$1.81B$6.78 - $21.950.00%
4350ABVC BioPharma, Inc.ABVC$1.06-0.95%23.09K$28.19M$0.71 - $3.060.00%

Deposit USD for Up to $520

First USD deposit earns $20 with 0 fees

Deposit USD for Up to $520

Trade U.S. stocks Your Way on MEXC

RealStocksTokenized StocksStock Futures
What it isRealStocks — real shares of U.S.-listed companiesBlockchain-based tokens linked to U.S. stocks/ETFsUSDT-margined futures on U.S. stock price movements
OwnershipYes — actual sharesNo — synthetic exposure onlyNo — derivative exposure only
Shareholder rightsYes (e.g. dividends)NoNo
Trading hoursU.S. market sessions (pre-market, regular, after-hours, overnight)24/7Up to 24/7 (supported pairs)
Position typesBuy and holdBuy and holdLong, short, leveraged
Best forLong-term investors seeking ownership and dividend incomeTraders wanting round-the-clock access to stock exposure without holding sharesActive/short-term traders looking to speculate or hedge with leverage

Why Trade U.S. stocks on MEXC?

RealStocks, Real Ownership

Buy real US-listed shares through MEXC's partner licensed broker and receive applicable shareholder benefits, including dividends.

7,000+ U.S. stocks & ETFs

Access 7,000+ US-listed stocks and ETFs across technology, finance, healthcare, consumer sectors, and more.

Seamless USDT-to-Stock Access

Transfer USDT and convert between USDT and USD to fund your RealStocks account with ease.

Lower-Cost Stock Trading

Trade real U.S. stocks with competitive costs and keep more capital available for your investment strategy.

Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
Aprea Therapeutics, Inc. (APRE) currently leads with a 52-week gain of 61.19% as of 2026-10-28 02:55 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.